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Friday, December 3, 2021

Progesterone recommended to prevent early miscarriage


Women who experience bleeding in early pregnancy and have had at least one miscarriage should be treated with the hormone progesterone.

The new NICE guidance is based on research that suggests the treatment could result in 8,450 more births in the UK each year.

The trial discovered that the more miscarriages a woman had, the more effective progesterone was.

The naturally occurring hormone aids in the preparation of the womb for the growing baby.

Josie is 15 weeks into her sixth pregnancy after five miscarriages.

It is her longest so far, and while it is impossible to say whether her progesterone treatment is to blame, it has made a significant difference in how she feels.

Josie and David: “All we’ve ever wanted is to become parents”

“If this is what makes it okay for us… it’s just miraculous,” she says.

“All we’ve ever wanted is to have children.”

“So, to actually get this far, to have the opportunity, and to have the progesterone, it gives us tremendous hope.”

Bleeding continues

Approximately one in every five women will experience bleeding, or spotting as it is sometimes referred to, during the first 12 weeks of pregnancy.

It usually causes no problems, but they should check with their doctor or midwife to be sure.

Some women may have a “threatened miscarriage,” in which bleeding continues throughout the pregnancy.

Most are advised to return home and wait to see what happens next.

The National Institute for Health and Care Excellence (NICE) now recommends inserting progesterone pessaries into the vagina twice daily.

Josie was prescribed it by doctors at Birmingham Women’s Hospital.

The new guidance is based on a trial conducted by researchers at the Tommy’s National Centre for Miscarriage Research, which found that progesterone didn’t make much of a difference for women who only had bleeding and no previous miscarriages.

However, the more miscarriages a woman had, the more effective progesterone was.

Best treatments

Prof Arri Coomarasamy of the University of Birmingham, one of the researchers behind Tommy’s National Centre for Miscarriage Research, stated, “This is a very significant moment.” We have a successful intervention that can prevent a miscarriage.” This gives thousands of couples in the United Kingdom hope.

“However, it is critical to recognise that progesterone can only prevent some miscarriages.

“There are other causes for miscarriages.

“We still need to study them.

“We need to find other effective treatment.”

Miscarriage occurs in one out of every four pregnancies, with the vast majority occurring in the first few months or trimester.

“It is encouraging that NICE has acknowledged the most recent evidence,” said Dr. Edward Morris, president of the Royal College of Obstetricians and Gynaecologists.

We do, however, have a long way to go before we understand the best treatments for women experiencing unexplained pregnancy loss, and we would welcome additional research in this area.”

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